the Prakash Lab

1.   Marié I, Smith EJ, Prakash A, Levy DE.(2000). Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain. Molecular and Cellular Biology, 20(23):8803-14.

           

2.   Smith EJ, Marié I, Prakash A, Garcia-Sastre A, Levy DE. (2001). IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein. Journal of Biological Chemistry, 276(12):8951-7.

           

3.   Levy DE, Marié I, Smith EJ, Prakash A. (2002). Enhancement and diversification of IFN induction by IRF-7-mediated positive feedback. Journal of Interferon and Cytokine Research, 22(1):87-93.

             

4.   Caillaud A, Prakash A, Smith EJ, Masumi A, Hovanessian AG, Levy DE, Marié I. (2002). Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. Journal of Biological Chemistry, 277(51):49417-21

           

5.   Levy DE, Marié I, Prakash A. (2003). Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity. Current Opinions in Immunology, 15(1): 52-8

           

6.   Prakash A, Smith EJ, Lee CK, Levy DE. (2005). Tissue-specific positive feedback requirements for production of type I interferon following virus infection. Journal of Biological Chemistry, 280(19):18651-7.

           

7.   Prakash A, Levy DE. (2006). Regulation of IRF7 through cell type-specific protein stability. Biochemical and Biophysical Research Communications, 342(1):50-6.

           

8.   Prakash A and Hellman J. (2010). Pattern Recognition Receptors and Factor B: “Complement”ary Pathways Converge. Journal of Leukocyte Biology, 88(4):605-7.

           

9.   Shin H-S, Xu F, Bagchi A, Herrup E, Prakash A, Valentine C, Kulkarni H, Wilhelmsen K, Warren S, Hellman J. (2011). Bacterial Lipoprotein TLR2 Agonists Broadly Modulate Endothelial function and Coagulation Pathways In Vitro and In Vivo. Journal of Immunology, 186(2):1119-30.

 

10. Wilhelmsen K, Mesa KR, Prakash A, Xu F, Hellman J. (2011). Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil response. Innate Immunity, Dec 20 [Epub ahead of print].

 

11. Prakash A, Mesa KR, Wilhelmsen K, Xu F, Dodd-o JM, Hellman J. (2012). Alveolar macrophages and TLR4 mediate lung ischemia reperfusion injury. Anesthesiology, 117(4):822-835.

 

12. Breyer KEW, Ou J, Durack JC, Prakash A. (2012). Prolonged profound hypoxia and cardiac failure in a young female presenting to the emergency department: unexpected pulmonary embolus, catheter-directed thrombolysis, and subsequent multi-organ failure. ICU Director, 3(5):215-219.

 

13. Zhang N, Francis KP, Prakash A, Ansaldi D. (2013). Enhanced detection of myeloperoxidase activity in deep tissues through luminescent excitation of near-infrared nanoparticles. Nature Medicine, 19(4):500-5.

 

14. Wilhelmsen K, Xu F, Farrar K, Tran A, Khakpour S, Sundar S, Prakash A, Wang J, Gray NS and Hellman J. Extracellular Signal-Regulated Kinase 5 / Big MAP Kinase 1 (ERK5 / BMK1) Promotes Acute Cellular and Systemic Inflammation. Science Signaling. 2015 In Press.